Custom Peptides
Cayman Chemical BTS-54-505hydrochlorIde 10mg
An active metabolite of sibutramine; inhibits norepinephrine, 5-HT, and dopamine uptake in rat cortical synaptosomes (IC50s = 0.066, 5.1, and 0.61 µM, respectively); prevents reserpine-induced ptosis in rats (ED50 = 3.7 mg/kg); decreases immobility in the Porsolt learned helplessness test in mice at 10 mg/kg; increases colonic temperature and decreases food intake in rats at 10 mg/kg
Cayman Chemical 4NItrophenyl aLrhamnopyrn 10mg
A colorimetric naringinase substrate; upon hydrolysis by the α-rhamnosidase subunit of naringinase, 4-nitrophenol is released which can be quantified by colorimetric detection at 405 nm as a measure of naringinase α-rhamnosidase activity; has been used in the detection of naringinase α-rhamnosidase activity in various bacteria
Cayman Chemical 4MethylumbelIferyl DN N 10mg
A fluorogenic substrate for chitinases and chitobiosidases; cleaved by chitinases and chitobiosidases to release the fluorescent moiety 4-ΜU; ex/em = 320 and 360 at low (1.97-6.72) and high pH (7.12-10.3), respectively/445-455 nm, increasing as pH decreases
Cayman Chemical MagnolIae flos asrInIn 10mg
A lignan; an inhibitor of Δ5-desaturase (Ki = 0.28 mM); selective for Δ5-desaturase over Δ6- and Δ9-desaturase; cytotoxic to A2780 and SKOV3 ovarian cancer cells (IC50s = 38.45 and 60.87 µM, respectively) but not immortalized ovarian surface epithelial cells (IC50 = >200 µM)
Cayman Chemical DIltIazem-d3hydrochlorIde 10mg
An internal standard for the quantification of diltiazem by GC- or LC-MS
Cayman Chemical 5 7 3 4 5Pentamethoxyflav 10mg
A flavonoid with diverse biological activities; inhibits pancreatic lipase in a cell-free assay; reduces lipid accumulation in 3T3-L1 adipocytes; inhibits transactivation of Nrf2 in a reporter assay using HEK293T cells at 10, 25, or 50 µM; sensitizes cisplatin-resistant A549 NSCLC cells to cisplatin; inhibits LPS-induced NO production in RAW 264.7 macrophages and GES-1 cells; decreases blood glucose levels and renal fibrosis in a rat model of STZ-induced diabetes at 5 mg/kg
Cayman Chemical NorcholIc AcId 10mg
A bile acid and derivative of cholic acid; urine levels are increased in patients with liver cirrhosis or CTX
Cayman Chemical ChenodeoxycholylputrescIn 10mg
A polyamine bile amidate; has been found in lion, but not mouse, fecal samples; has been used as a standard in the detection of chenodeoxycholyl-putrescine in mammalian intestinal and fecal samples
Cayman Chemical GInkgonlIc AcId 10mg
An anacardic acid with diverse biological activities; inhibits GPDH (IC50 = 3 μg/ml); inhibits PI3Kδ (IC50 = 2.49 μM) and IgE-mediated RBL-2H3 mast cell degranulation in vitro (IC50 = 2.4 μM); reduces S. mutans biofilm formation (MBIC50 = 4 μg/ml)
Cayman Chemical IT1thydrochlorIde 10mg
A CXCR4 antagonist (IC50s = 8 and 11 nM for the human and rat receptors, respectively); selective for CXCR4 over hERG/Kv11.1 (IC50 = 13,240 nM); inhibits CXCL12-induced calcium mobilization in CEM cells (IC50 = 1.1 nM) and decreases CXCL12-induced migration of Jurkat cells (IC50 = 79.1 nM); inhibits replication of the HIV-1 strain NL4-3 in MT-4 cells and isolated PHA-stimulated PBMCs; reduces tumor growth in an MDA-MB-231-B zebrafish xenograft model at 20 µM
Cayman Chemical RoseoflavIn 10mg
A riboflavin analog that possesses antimicrobial activity; binds directly to FMN riboswitch aptamers (KD = ~100 nM), downregulating the expression of genes responsible for the synthesis and transport of riboflavin
Cayman Chemical VardenafIlhydroCLOrID hyd 10mg
An inhibitor of PDE5 (IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM); selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively); improves erectile dysfunction in a rat model of acute arteriogenic erectile dysfunction; reduces the latency to mount and increases the frequency of mounting in mice after chronic treatment at 2 mg/kg for five weeks